ChloroquineV1, Main, Exploration, bibRecord, 001E02

Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.

Identifieur interne : 001E02 ( Main/Exploration ); précédent : 001E01; suivant : 001E03

Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.

Auteurs : Guédé Noël Zirihi ; Philippe Grellier [France] ; Frédérick Guédé-Guina ; Bernard Bodo [France] ; Lengo Mambu [France]

Source :

Bioorganic and Medicinal Chemistry Letters [ 0960-894X ] ; 2005-05-16.

RBID : Hal:hal-00171107

Abstract

Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values ranging from 0.97 to 3.39 microM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 microM.

Url:

https://hal.archives-ouvertes.fr/hal-00171107

DOI: 10.1016/j.bmcl.2005.03.021

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000145
to stream Hal, to step Curation: 000145
to stream Hal, to step Checkpoint: 000237
to stream Main, to step Merge: 001E17
to stream Main, to step Curation: 001E02

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.</title>
<author><name sortKey="Zirihi, Guede Noel" sort="Zirihi, Guede Noel" uniqKey="Zirihi G" first="Guédé Noël" last="Zirihi">Guédé Noël Zirihi</name>
</author>
<author><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-134773" status="OLD">          <orgName>Molécules de Communication et Adaptation des Micro-Organismes</orgName>
          <orgName type="acronym">MCAM</orgName>
          <date type="end">2010-12-31</date>
          <desc>            <address>              <addrLine>57 rue Cuvier - 75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-7512" type="direct"></relation>
            <relation name="FRE3206" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-7512" type="direct"><org type="institution" xml:id="struct-7512" status="VALID">          <orgName>Muséum national d'Histoire naturelle</orgName>
          <orgName type="acronym">MNHN</orgName>
          <desc>            <address>              <addrLine>57, rue Cuvier - 75231 Paris Cedex 05</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.mnhn.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="FRE3206" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Guede Guina, Frederick" sort="Guede Guina, Frederick" uniqKey="Guede Guina F" first="Frédérick" last="Guédé-Guina">Frédérick Guédé-Guina</name>
</author>
<author><name sortKey="Bodo, Bernard" sort="Bodo, Bernard" uniqKey="Bodo B" first="Bernard" last="Bodo">Bernard Bodo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">          <orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
          <desc>            <address>              <addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UMR5154" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR5154" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mambu, Lengo" sort="Mambu, Lengo" uniqKey="Mambu L" first="Lengo" last="Mambu">Lengo Mambu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">          <orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
          <desc>            <address>              <addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UMR5154" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR5154" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00171107</idno>
<idno type="halId">hal-00171107</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00171107</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00171107</idno>
<idno type="doi">10.1016/j.bmcl.2005.03.021</idno>
<date when="2005-05-16">2005-05-16</date>
<idno type="wicri:Area/Hal/Corpus">000145</idno>
<idno type="wicri:Area/Hal/Curation">000145</idno>
<idno type="wicri:Area/Hal/Checkpoint">000237</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000237</idno>
<idno type="wicri:doubleKey">0960-894X:2005:Zirihi G:isolation:characterization:and</idno>
<idno type="wicri:Area/Main/Merge">001E17</idno>
<idno type="wicri:Area/Main/Curation">001E02</idno>
<idno type="wicri:Area/Main/Exploration">001E02</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.</title>
<author><name sortKey="Zirihi, Guede Noel" sort="Zirihi, Guede Noel" uniqKey="Zirihi G" first="Guédé Noël" last="Zirihi">Guédé Noël Zirihi</name>
</author>
<author><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-134773" status="OLD">          <orgName>Molécules de Communication et Adaptation des Micro-Organismes</orgName>
          <orgName type="acronym">MCAM</orgName>
          <date type="end">2010-12-31</date>
          <desc>            <address>              <addrLine>57 rue Cuvier - 75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-7512" type="direct"></relation>
            <relation name="FRE3206" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-7512" type="direct"><org type="institution" xml:id="struct-7512" status="VALID">          <orgName>Muséum national d'Histoire naturelle</orgName>
          <orgName type="acronym">MNHN</orgName>
          <desc>            <address>              <addrLine>57, rue Cuvier - 75231 Paris Cedex 05</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.mnhn.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="FRE3206" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Guede Guina, Frederick" sort="Guede Guina, Frederick" uniqKey="Guede Guina F" first="Frédérick" last="Guédé-Guina">Frédérick Guédé-Guina</name>
</author>
<author><name sortKey="Bodo, Bernard" sort="Bodo, Bernard" uniqKey="Bodo B" first="Bernard" last="Bodo">Bernard Bodo</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">          <orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
          <desc>            <address>              <addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UMR5154" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR5154" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mambu, Lengo" sort="Mambu, Lengo" uniqKey="Mambu L" first="Lengo" last="Mambu">Lengo Mambu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-19260" status="VALID">          <orgName>Laboratoire de Chimie et Biochimie des Substances Naturelles</orgName>
          <desc>            <address>              <addrLine>Département RDDM Case Postale 54 57 rue Cuvier F 75005 PARIS</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation name="UMR5154" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle name="UMR5154" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.bmcl.2005.03.021</idno>
<series><title level="j">Bioorganic and Medicinal Chemistry Letters</title>
<idno type="ISSN">0960-894X</idno>
<imprint><date type="datePub">2005-05-16</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Bioassay-guided fractionation of the EtOH extract of the stem bark of Funtumia elastica resulted in the isolation of four steroidal alkaloids, holarrhetine (1), conessine (2), holarrhesine (3) and isoconessimine (4). Their structures were determined on the basis of 1D- and 2D-NMR techniques and mass spectrometry. Compounds 1-4 exhibited in vitro antiplasmodial activity against the chloroquine-resistant strain FcB1 of Plasmodium falciparum with IC50 values ranging from 0.97 to 3.39 microM. They showed weak cytotoxicity against a rat cell line L-6 with IC50 values ranging from 5.13 to 36.55 microM.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Guede Guina, Frederick" sort="Guede Guina, Frederick" uniqKey="Guede Guina F" first="Frédérick" last="Guédé-Guina">Frédérick Guédé-Guina</name>
<name sortKey="Zirihi, Guede Noel" sort="Zirihi, Guede Noel" uniqKey="Zirihi G" first="Guédé Noël" last="Zirihi">Guédé Noël Zirihi</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
</noRegion>
<name sortKey="Bodo, Bernard" sort="Bodo, Bernard" uniqKey="Bodo B" first="Bernard" last="Bodo">Bernard Bodo</name>
<name sortKey="Mambu, Lengo" sort="Mambu, Lengo" uniqKey="Mambu L" first="Lengo" last="Mambu">Lengo Mambu</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E02 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E02 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Hal:hal-00171107
   |texte=   Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.

Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri